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A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases based on Blood Tests Article

Gege Hou,Yunru Chen,Xiaojing Liu,Dong Zhang,Zhimin Geng,Shubin Si

Engineering 2024, Volume 32, Issue 1,   Pages 174-185 doi: 10.1016/j.eng.2023.06.013

Abstract:

Chronic hepatitis B virus (HBV) infection, which threatens global publichealth, is a major contributor to liver-related morbidity and mortality.Examinations for liver diseases related to chronic HBV infection—including laboratory tests, ultrasoundsestablish an economical and effective diagnosis method in order to streamline the medical process for HBV-relateddiseases.

Keywords： HBV-related diseases     Functional resilience     Improve medical resource utilization     Critical states     Network    

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The critical importance of epigenetics in autoimmune-related skin diseases

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 43-57 doi: 10.1007/s11684-022-0980-8

Abstract: Autoimmune-related skin diseases are a group of disorders with diverse etiology and pathophysiology involved, we discuss the most recent findings regarding the function of epigenetic mechanisms in autoimmune-relatedskin disorders, including systemic lupus erythematosus, bullous skin diseases, psoriasis, and systemic

Keywords： epigenetics     autoimmune-related skin diseases     DNA methylation     histone modifications     noncoding RNAs    

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Primary cilia in hard tissue development and diseases

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 657-678 doi: 10.1007/s11684-021-0829-6

Abstract: Hard tissue diseases have a serious effect on human survival and quality of life.Mutations in cilium-related genes result in a variety of developmental and even lethal diseases.In addition, the cilium-related diseases of hard tissue and the manifestations of mutant cilia in theWe believe that all the findings will help with the intervention and treatment of related hard tissuegenetic diseases.

Keywords： primary cilia     bone     mechanical sensing     hard tissue     cilium-related bone disease     tooth    

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Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission

Xiaohong Shi, Xuefei Wang, Xixi Xu, Yongliang Feng, Shuzhen Li, Shuying Feng, Bo Wang, Suping Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 548-553 doi: 10.1007/s11684-017-0597-5

Abstract: Within 24 h after birth, HBV serological markers, serum HBV DNA, PBMC HBV relaxed circular DNA (rcDNAThe relationship between HBV replication in PBMC and HBV intrauterine transmission was examined throughMaternal PBMC HBV cccDNA was a risk factor of HBV intrauterine transmission (OR= 6.003, 95% CI: 1.249&The positivity of PBMC HBV rcDNA was related to that of cccDNA in the HBsAg-positive mothers (cHBV intrauterine transmission.

Keywords： PBMC     HBV cccDNA     HBV rcDNA     HBV intrauterine transmission    

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Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 158-165 doi: 10.1007/s11684-014-0340-4

Abstract:

Hepatitis B remains a leading cause of cirrhosis, hepatocellular carcinoma and liver transplantation worldwide. Management of chronic hepatitis B during pregnancy is challenging. Transmission of hepatitis B to infants still occurs perinatally although immunoprophylaxis is widely available for infants born to mothers with chronic hepatitis B infection. The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimester in highly viremic mothers can prevent immunoprophylaxis failure in their infants. The available drug safety data show that lamivudine, telbivudine and tenofovir are generally safe to be used during the pregnancy. In order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancy should be limited to a selected group of patients with cirrhosis, high hepatitis B viral load, or prior history immunoprophylaxis failure. An elective Caesarean section may reduce the risk of perinatal transmission. For those females planning for pregnancy or in early stage of pregnancy, communication and follow-up among obstetrician, gastroenterologist, and primary care physician are important. In this article, we will review the features of hepatitis B infection before, during and after the pregnancy; the risk factors that increase mother-to-child transmission; safety data on antiviral drug use during pregnancy; and the potential role of Caesarean section in selected cases.

Keywords： antiviral therapy     Caesarean section     cirrhosis     hepatitis B     immunoprophylaxis     mother-to-child transmission     pregnancy     prevention    

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New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 129-134 doi: 10.1007/s11684-014-0339-x

Abstract:

Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormousMechanisms responsible for chronic HBV infection remain poorly understood.Natural course of chronic HBV infection is conventionally viewed as an uninterrupted process that iswith assumed host responses to HBV infection.and reinfection, and such cycles prolong the chronic HBV infection course.

Keywords： hepatitis B virus     chronic HBV infection     natural course     hepatitis B     seroconversion    

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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract: In this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the lifecycle of HBV replication, and the potential significance of serum HBV RNA is systematically describedThe production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBVTherefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBVDNA fragment, serum HBV RNA, with pregenomic RNA origination, can only be transcribed from cccDNA.

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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Eliminating mother-to-child transmission of HBV: progress and challenges in China

Wenzhan Jing, Jue Liu, Min Liu

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 21-29 doi: 10.1007/s11684-020-0744-2

Abstract: China has the world’s largest burden of hepatitis B virus (HBV) infection, but the country has made considerableStudies on the optimal antiviral treatment regimen for pregnant women with high HBV-DNA load have alsoHowever, China still faces challenges in eliminating MTCT of HBV.than that of the national level because of limited health resources and public health education for HBVIntegration of current services to prevent MTCT of HBV with other relevant health services can increase

Keywords： hepatitis B virus     mother-to-child transmission     progress     challenge    

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Laparoscopic treatment of liver diseases in children

Jia Wei, Jiexiong Feng

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 388-394 doi: 10.1007/s11684-011-0165-3

Abstract: Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases overapplication of various laparoscopic instruments and the methods used for the laparoscopic treatment of liver diseases

Keywords： laparoscopic surgery     liver mass     pediatric    

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Prevalence of cardiovascular diseases in China

Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 16-20 doi: 10.1007/s11684-010-0007-8

Abstract: Cardiovascular diseases (CVD) cause one third of all deaths in China, and the number is anticipated to

Keywords： cardiovascular diseases     prevalence     China     risk factors     prevention    

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Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 389-394 doi: 10.1007/s11684-013-0281-3

Abstract: Specifically, we suggest that an undiagnosed diseases program in China will differ from the recentlyestablished Undiagnosed Diseases Program at the United States National Institutes of Health; a culturally

Keywords： genetics     cultural differences     undiagnosed diseases program    

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Diagnosis and therapy of lacrimal system diseases by micro lacrimal endoscope

Nan XIANG, Weikun HU, Jing YUAN, Guigang LI, Haixia LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 113-117 doi: 10.1007/s11684-009-0001-1

Abstract: membranes, the characteristics of pathological changes and the predilection sites of lacrimal system diseasesThe lacrimal endoscope is a new method in the diagnosis of lacrimal system diseases.therapy under orthophoria, it will bring a great change to the diagnosis and therapy of lacrimal system diseases

Keywords： lacrimal apparatus diseases     endoscopes    

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Responses to emerging and re-emerging infectious diseases: One world, One health

Jianqing Xu, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 1-2 doi: 10.1007/s11684-018-0619-y

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A Study on the Prevention and Control of Major Chronic Non-communicable Diseases Abroad

Zhang Zhuqin and Liu Depei

Strategic Study of CAE 2017, Volume 19, Issue 2,   Pages 112-116 doi: 10.15302/J-SSCAE-2017.02.019

Abstract:

Major chronic non-communicable diseases, including cardiovascular andcerebrovascular diseases, cancer, respiratory diseases, and diabetes, are prevalent in China and aroundIn order to effectively prevent and control chronic diseases, enhance national health, and promote economicThis project conducted a series of studies on the prevention and control of chronic diseases at homeBased on the project report, this paper describes the prevention and control of various chronic diseases

Keywords： chronic non-communicable diseases     cardiovascular and cerebrovascular diseases     cancer     respiratory diseases    

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Projections of heat-related excess mortality in China due to climate change, population and aging

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 11, doi: 10.1007/s11783-023-1732-y

Abstract:

● Four scenarios were used to project heat-related excess mortality

Keywords： Heat-related excess mortality     LMDI     Aging     YLL     VSLY    

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Title Author Date Type Operation

A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases based on Blood Tests

Gege Hou,Yunru Chen,Xiaojing Liu,Dong Zhang,Zhimin Geng,Shubin Si

Journal Article

The critical importance of epigenetics in autoimmune-related skin diseases

Journal Article

Primary cilia in hard tissue development and diseases

Journal Article

Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission

Xiaohong Shi, Xuefei Wang, Xixi Xu, Yongliang Feng, Shuzhen Li, Shuying Feng, Bo Wang, Suping Wang

Journal Article

Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Journal Article

New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Journal Article

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

Eliminating mother-to-child transmission of HBV: progress and challenges in China

Wenzhan Jing, Jue Liu, Min Liu

Journal Article

Laparoscopic treatment of liver diseases in children

Jia Wei, Jiexiong Feng

Journal Article

Prevalence of cardiovascular diseases in China

Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,

Journal Article

Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Journal Article

Diagnosis and therapy of lacrimal system diseases by micro lacrimal endoscope

Nan XIANG, Weikun HU, Jing YUAN, Guigang LI, Haixia LIU

Journal Article

Responses to emerging and re-emerging infectious diseases: One world, One health

Jianqing Xu, Jianguo Xu

Journal Article

A Study on the Prevention and Control of Major Chronic Non-communicable Diseases Abroad

Zhang Zhuqin and Liu Depei

Journal Article

Projections of heat-related excess mortality in China due to climate change, population and aging

Journal Article